We have had 3 cases of cardiac arrest after a dose of ceftriaxone via IV push, one case in 2020, and two more cases recently. None of these cases had any other features of typical anaphylactic reactions (no hives, swelling, etc.).

Have any other sites experienced similar cases? If so, what were the details of the events? Do you believe the rate of IV push increases the risk of these reactions?

Any information would be much appreciated!

Hello!

Does your organization have an age or weight limit for which you would NOT reconstitute IM ceftriaxone with lidocaine?

If you have restrictions in place, are they the same in both the inpatient and outpatient/ambulatory settings? How do you enforce any established practices (policy, pharmacy, CPOE, etc.)?

Any commentary or experience would be much appreciated! Thanks in advance!
Emily