Has anyone had success in developing clinical decision support/alerts in Epic to mitigate the risk of respiratory depression, secondary to opioid stacking?

With ISMP's survey results about the implementation for the newest two best practices for hospitals, it is brutally apparent that many of us have a long way to go with opioid stewardship. Specifically with identification of opioid-tolerant vs. opioid-naive patients prior to verification of extended released opoioids. Only 15% being fully implemented.