Focusing on severe sepsis and septic shock as defined by CMS, we are interested in administering broad-spectrum antibiotic coverage (which typically will require at least two different antibiotics) as rapidly as possible. Often times, antibiotics are Y-site compatible making it feasible to administer two antibiotics simultaneously. However, there is a theoretical concern that a patient could develop an allergic reaction, and if both antibiotics were infusing simultaneously, it would be difficult to determine which antibiotic is responsible for the reaction.