Are you aware of a single-dose, or a one-day regimen for dexrazoxane used for the treatment of anthracycline extravasation? If so, could you please share your regimen/reference?

FDA-approved dosing is for a three-day regimen (1000 mg/m2 on days 1 and 2 infused over 1-2 hours, and 500 mg/m2 on day 3).

Thank you.

If administering vinca alkaloids as an IVPB, does pharmacy dispense with primary or secondary tubing?

On a related note, if using secondary tubing, what is the nursing procedure in case of an infusion reaction?

Thank you,
Daniel

If administering vinca alkaloids via IV bag, is your practice to administer the medication via gravity infusion without a pump, or do you use an infusion pump and program as rapid infusion (e.g. 10 mins)?

Have you had any issues or seen disadvantages with administering as a gravity infusion without pumps?

Thank you,
Daniel

We are in the process of implementing interoperability between smart pumps and EMR. During this process we have identified that our EMR is setup to have a dual verification for chemotherapy rate changes. This is not something that was forced before but when completing the pump rate verify it ask for each rate change to be dual verified.

The standards from ONS suggest a dual verification for initial pump programming but do not go into detail regarding rate changes. APON suggest a dual verification for initial pump programming and rate changes of chemotherapy.