ceftriaxone/LR or Calcium incompatibility

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Thu, 07/28/2022 - 15:25
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Julie Neuman
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ceftriaxone/LR or Calcium incompatibility

We are experiencing increased use of LR as maintenance fluids. How are institutions handling Y-site administration of ceftriaxone with LR? Trissel’s does show one study compatible for 4 hours with ceftriaxone 100 mg/ml y-site administration with LR, but all other studies incompatible.
Do you allow Y-site administration of ceftriaxone with LR?
Do you recommend a flush before and after to mitigate potential precipitation?
If so, what volume is sufficient to flush for compatibility concerns?
Do you use the same line for intermittent calcium infusions and ceftriaxone administration and flush between the medications?
If yes, what volume is sufficient to run between these incompatible agents?

Julie Neuman, Pharm. D.
Medication Safety Specialist
Benefis Hospitals
Great Falls, MT
julieneuman@benefis.org

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