Duloxetine / Feeding Tube Route

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Wed, 02/28/2024 - 15:45
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Jake Regnitz
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Joined: 01/17/2024 - 16:55
Duloxetine / Feeding Tube Route

Good day all,

Curious if anyone is allowing duloxetine capsules to be opened for feeding tube administration, etc?

The generic products (not Drizalma which has been discontinued) appear to have been reformulated to have smaller sprinkles within the capsules that a small enough to pass through a feeding tube. In addition, there appears to be a study supporting stability and this practice. https://www.sciencedirect.com/science/article/abs/pii/S0149291808800549?...

The FDA (post market) did recommend additional warnings to labels when opening capsules. Reported issues from Circa 2005-2006 were a report of increased BP, a report of esophageal burning, and gastritis.

For ICU patients, there have been studies showing positive impact on vent days when psych meds are continued so would like to continue this medication if can be done so safely.

Thank you!

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