Hyaluronidase for extravasation via IV catheter dose/directions

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Wed, 12/20/2023 - 09:03
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Scott Murray
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Joined: 06/11/2015 - 13:37
Hyaluronidase for extravasation via IV catheter dose/directions

Does anyone have better directions when Hyaluronidase is administered via the IV catheter?
Lexicomp states "Intradermal or SUBQ: Inject a total of 1 mL (15 units/mL) as 5 separate 0.2 mL injections (using a tuberculin syringe) around the site of extravasation; if IV catheter remains in place, administer IV through the infiltrated catheter; may repeat in 30 to 60 minutes if no resolution (Ref)."

Does the above mean to administer the 1ml volume that would have been administered intradermal, via the IV catheter?

If so should/could we do both, since not concerned for toxicity?

The package insert does not offer any clarity and a cursory literature search does not specify directions beyond use IV catheter if still in place.

Regards,
Scott

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