Naloxone drip concentration

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Wed, 05/21/2025 - 13:18
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Abhiruchi Mehta
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Joined: 01/24/2024 - 15:37
Naloxone drip concentration

Hello,

Our institution currently has 2 naloxone infusion concentrations:
1. 4mcg/ml (2mg in 500ml)
2. 16mcg/ml (4mg in 250ml) for Narcotic OD

In reviewing resources, both Micromedex and manufacturer package insert recommend diluting 2mg in 500ml and I am trying to identify the reference for the higher concentration.

ASHP S4S lists 16 mcg/mL as the standardized concentration. However, the resources listed in the S4S document do not mention that concentration.

I would appreciate your input in what naloxone infusion concentrations are utilized by your institution.

Thank you!

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