Options for heparin resistance in critically ill patients

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Mon, 12/18/2017 - 14:57
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Leah Cochran
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Joined: 09/30/2013 - 13:18
Options for heparin resistance in critically ill patients

We have recently switched to monitoring heparin assays for our weight based heparin drips and have had several situations where the heparin assays have remained subtherapeutic despite high doses of heparin (>25units/kg/hr). This has been occurring more in our critical care population. Has anyone encountered the same issue and have any guidance on how to manage ( argatroban vs giving thrombin vs alternative monitoring vs other) thanks.

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