Protamine administration

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Mon, 01/06/2025 - 13:59
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Abhiruchi Mehta
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Protamine administration

Protamine administration is recommended in undiluted form, not to exceed 50mg dose over 10 minutes of slow IV push injection.

How does your institution administer protamine doses over 25mg that would need to be given over > 5minutes? Do you utilize a syringe pump or administer it by hand?

We do not stock syringe pumps on units, and they are supplied by materials management when requested. This poses an issue since protamine would be needed urgently and there may not be time to get a syringe pump.

We used to have an option to do IVPB but that was discontinued. Trying to establish best practice for administration while maintaining safety.

Thank you for your input!

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