Protamine adverse reactions

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Tue, 12/19/2017 - 13:37
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Beth Willis
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Joined: 06/08/2015 - 09:16
Protamine adverse reactions

Our institution seems to have had a recent uptick in life-threatening adverse reactions to protamine administration in the past couple of months (hypotension, pulmonary vasoconstriction, cardiovascular collapse). We have reported 4 cases to FDA MedWatch, but are interested if this increase has been noted at other institutions. We have not identified anything preventable upon review of the cases. Have any of you noticed this at your facilities?

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