Protamine adverse reactions

PLEASE NOTE:   Posts made to this forum should not be considered as the expressed opinions of, nor should be considered endorsed by, the Medication Safety Officer’s Society (MSOS) or the Institute for Safe Medication Practices (ISMP). 

Make sure your email is up-to-date
In order to continue to receive updates from MSOS, as well as forum posts and other valuable information as a member of MSOS, please be sure to update your email address with us, whenever it changes. If you need assistance doing so, please send an email to jrufo@ismp.org. 

6 posts / 0 new
Log in or register to post comments
Last post
Tue, 12/19/2017 - 13:37
#1
Beth Willis
Beth Willis's picture
Offline
Last seen: 1 week 6 days ago
Joined: 06/08/2015 - 09:16
Protamine adverse reactions

Our institution seems to have had a recent uptick in life-threatening adverse reactions to protamine administration in the past couple of months (hypotension, pulmonary vasoconstriction, cardiovascular collapse). We have reported 4 cases to FDA MedWatch, but are interested if this increase has been noted at other institutions. We have not identified anything preventable upon review of the cases. Have any of you noticed this at your facilities?

Top