For intermittent dosing of IV DHE for pediatric patients with migraines. Is there evidence to support dilution of the medication (stability). Have your team's extended the duration of administration beyond 2-3 minutes.

What evidence sources did you utilize for stability to dilute and extend the duration?

Lexicomp:
IV: Children ≥6 years and Adolescents: May be administered undiluted slowly over 2 to 3 minutes; or diluted and infused over 60 minutes (Ref). Test doses have been administered over 5 minutes