Andexanet alfa administration

PLEASE NOTE:   Posts made to this forum should not be considered as the expressed opinions of, nor should be considered endorsed by, the Medication Safety Officer’s Society (MSOS) or the Institute for Safe Medication Practices (ISMP). 

Make sure your email is up-to-date
In order to continue to receive updates from MSOS, as well as forum posts and other valuable information as a member of MSOS, please be sure to update your email address with us, whenever it changes. If you need assistance doing so, please send an email to

3 posts / 0 new
Last post
Jeanie Misko
Jeanie Misko's picture
Last seen: 8 months 2 weeks ago
Joined: 05/11/2020 - 23:44
Andexanet alfa administration

I'm an Australian pharmacist. We have recently had andexanet alfa approved in Australia and I have several concerns about its safe administration, particularly as in Australia we don't have 24/7 onsite pharmacy services and nursing staff make up the majority of the intravenous medications.

Does your institution utilise an empty bag to prepare andexanet (and if so, which brand/plastic)?
Do you have both the bolus and infusion in the same bag?
What do you use for flushing please given there is lack of compatibility data for common fluids?

Many thanks for any information you can share, it is really appreciated.

All the best