Cutting misoprostol tablets

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Nicholas Crites
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Cutting misoprostol tablets

Since misoprostol is considered a hazardous drug we currently cut the 100 mcg tablet into ¼ a tab (25 mcg) for our L&D areas. Our pharmacy staff has expressed concerns and issues cutting these tablets since they tend to break and crumble, making it difficult to consistently get an accurate ¼ tablet. I am interested to hear what other organizations are doing.

Do you cut misoprostol in pharmacy or do nurses cut on the floor?

If pharmacy does cut the tablet…
a. How do you package the ¼ tablet (e.g. MILT, strip packer, etc.)?
b. Have you found a tablet manufacturer that works better than others?
c. What type of tablet cutter do you use?