Daptomycin Stability

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Andrea Rai
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Joined: 01/05/2022 - 15:34
Daptomycin Stability

One of our pharmacists found an article regarding daptomycin stability that states that once reconstituted and injected into infusion bags, they can be stored for up to 7 days when stored at 2-8 degrees Celsius ("Stability of daptomycin reconstituted
vials and infusion solutions" by Sanchez-Rubio Ferrandez, et. al). Our current process is to give an expiration of 48 hours after injecting into the infusion bag if properly stored in the refrigerator. One of our concerns is that the stability study in this particular paper only used brand name Cubicin. Our hospital uses whichever generic brand is available to order from our supplier, so we do not use Cubicin routinely. I cannot find other studies supporting a 7 day refrigerated stability for daptomycin. We're trying to determine if we can extrapolate data from this study to generic preparations of daptomycin. Does anyone else use a 7 day stability on daptomycin after injection into the infusion bag when stored in the refrigerator? If so, what data do you have to support this extended stability? Thank you!