Dilution of IV phenytoin doses

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Thu, 11/05/2020 - 11:16
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Amaris Fuentes
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Dilution of IV phenytoin doses

Good morning - we are currently reviewing our practices with phenytoin IV administration. We offer opportunities to order both as IV push and IVPB and would like to move away from IV push. We, however, are finding information regarding final dilution of phenytoin to be no less than 5mg/mL, which would mean dilution of a typical 100mg in only 20cc. I am, however, not finding information on what the implications of further dilution in 50 or 100mL would be. Appreciate if others can share their phenytoin IV practices and dilutions.

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