I am looking for some guidance on when it is ok to use a midline instead of a picc line for certain antibiotics. I have researched this topic to death and still come up with conflicting answers. I know that if the pH is <5 or >9 or >600 mOsm/L the drug should be given via picc line but some drugs in the grey area like Ampicillin (pH 8-10) or Meropenem which seems to fall in these guidelines (pH=7.3-8.3 300mOsm/L)are still listed on most "central line only" reference charts. When I get calls from our nurses (we are a home infusion company) asking if a drug is ok for midline, most times the patient has already been getting it via PIV in the hospital even though the drug is recommended to be given by central line. I try to look at them on a case by case basis but with a greater push to use midlines instead of central lines, I am getting lots of calls. Just want to try to make it easier for our nurses to determine if using a midline is safe for the patient. TIA for your help.