We recently observed two patients experience severe and concerning reaction to carfilzomib. Both had tolerated this medication well in the past and were in good health the day of infusion. Lot# 1125072 was used and both patients experienced similar symptoms: nausea, vomiting, changes in mental status, profound weakness, and possible syncopal episode. One patient recovered, the other remains in ICU. Has anyone else seen a similar constellation of symptoms with this medication? Notifications to medwatch and the manufacturer are in process.
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