MSOS Discussion Board

Anaphylaxis to Vancomycin x 3

Sara Meyer's picture

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Hi everyone-
We have had three patients experience anaphylaxis and subsequent cardiac arrest after receiving vancomycin at one of our facilities. Two of the patients received the same LOT and exp. I have submitted a manufacturer and MedWatch report, and we are sending drug off for testing, but I wanted to see if anyone else has experienced something similar. I know anaphylaxis after vanc is possible, but rare, and its alarming that we have had three events somewhat close together.

Variable concentration products & Pump integration?

Jennifer Marie Soto Meyer's picture

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Hello safety colleagues! Hoping to hear insights from other sites live on pump/EHR integration regarding products that have a variable concentration. Examples of variable concentration products would be "factor products" such as Kcentra or products such as alpha-1 proteinase inhibitor.

1. Do you have any variable concentration products "in scope" with pump integration?
2. If yes can you share tips or would you be willing to connect?

Single Bolus Air-In-Line (AIL) Alarm Setting

Jason Topolski's picture

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Our infusion pump system now offers multiple Single Bolus Air-In-Line (AIL) Alarm Settings. At the lowest setting, it contributes to an enormous number of alerts. I understand that there are various causes to these alerts (e.g., nursing practice, characteristics of infusion, etc) as well as potential interventions; however, is there any guidance around what bubble size is considered clinically significant (or non-significant)? From my brief research on air embolism, it doesn't seem the highest pump setting would be of clinical concern.

ASHRM Patient Safety Tip Sheet - Medication Safety - ADE-ADR Definition

Kirsten Parker's picture

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Recently ASHRM has posted a Medication Safety Tip Sheet that provides a succinct overview on Medication Errors and Recommendations.
https://www.ashrm.org/system/files/media/file/2025/02/Medication-Safety-...

I would be interested in others thoughts on their definition for Adverse Drug Reactions as "side effects experienced by patients even when there is no error (PSNet 2019, NCCMERP 2015)."

NICU SMOFLipids and Filters

Rachael Schortemeyer's picture

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Hey Everyone!

Our NICU is experiencing issues with SMOFlipids (potentially intralipid as well, they are just calling out SMOF as this is the primary lipid we use in our premature neonates) backing up, specifically when being administered via 1.4F PICC lines.

1.If you use SMOFlipids - what filter are you using, and have you experienced clogged filters or other issues with the infusion (particularly with extremely low rates)?

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